Synthesis of 4-alkylamino-6-arylamino-5-nitrosopyrimidines via intramolecular oxidation-reduction reactions of N-alkyl-N-(6-arylamino-5-nitropyrimidin-4-yl)glycinates
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چکیده
منابع مشابه
Investigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides.
In this study, a series of twenty-two 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides and ten 4-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides is described. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against mycobacterial, bacterial and fungal strains. They were al...
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In the title compound, C(18)H(17)N(5)O(2), the pyrimidine ring makes dihedral angles of 66.09 (12), 71.39 (13) and 56.7 (3)° with two phenyl rings and the nitro group, respectively. The dihedral angle between the two phenyl rings is 44.05 (14)°.
متن کامل6-Chloro-N-methyl-5-nitro-N-phenylpyrimidin-4-amine
In the title compound, C(11)H(9)ClN(4)O(2), the dihedral angle between the aromatic rings is 79.67 (8)°. π-π stacking between centrosymmetrically related pairs of pyrimidine rings occurs along [100] [centroid-centroid separations = 3.4572 (8) and 3.5433 (7) Å].
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In the title compound, C(11)H(11)ClN(4)O(3)S, the S atom is bonded in a distorted tetra-hedral geometry, by two O atoms, a C atom of the benzene ring and an amino N atom. The essentially planar pyrimidine ring [maximum deviation = 0.020 (1) Å] forms a dihedral angle of 87.57 (5)° with the benzene ring. In the crystal structure, pairs of mol-ecules are linked by inter-molecular N-H⋯O hydrogen bo...
متن کاملSynthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles
N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2018
ISSN: 1551-7012
DOI: 10.24820/ark.5550190.p010.682